Grandilodines A-C, biologically active indole alkaloids from Kopsia grandifolia

  • J Nat Prod. 2011 May 27;74(5):1309-12. doi: 10.1021/np200008g.
Wai-Sum Yap  1 ,  Chew-Yan Gan ,  Yun-Yee Low ,  Yeun-Mun Choo ,  Tadahiro Etoh ,  Masahiko Hayashi ,  Kanki Komiyama ,  Toh-Seok Kam
Affiliations
  • 1. Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
PMID: 21428274 DOI: 10.1021/np200008g
Abstract

Three new Indole Alkaloids (1-3), named grandilodines A-C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established using NMR and MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8) were found to reverse multidrug resistance in vincristine-resistant KB cells.