Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity

  • Eur J Med Chem. 2011 Aug;46(8):3462-8. doi: 10.1016/j.ejmech.2011.05.011.
C Kurumurthy  1 ,  P Sambasiva Rao ,  B Veera Swamy ,  G Santhosh Kumar ,  P Shanthan Rao ,  B Narsaiah ,  L R Velatooru ,  R Pamanji ,  J Venkateswara Rao
Affiliations
  • 1. Fluoroorganic Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India.
PMID: 21632155 DOI: 10.1016/j.ejmech.2011.05.011
Abstract

A series of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives 5 and 6 was prepared starting from 2,3-active functional pyridine 1via cyclization, propargylation followed by reaction with alkyl or perfluoroalkyl azides under Sharpless conditions. All the compounds 5 and 6 were screened for Anticancer activity against three Cancer cell lines such as U(937), THP-1 and Colo205. The promising compounds 5b and 5e have been identified.