Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template

  • ACS Med Chem Lett. 2011 May 12;2(5):391-395. doi: 10.1021/ml200020h.
Xing-Cong Li  1 ,  K Suresh Babu ,  Melissa R Jacob ,  Shabana I Khan ,  Ameeta K Agarwal ,  Alice M Clark
Affiliations
  • 1. National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, Mississippi 38677.
PMID: 21743827 DOI: 10.1021/ml200020h
Abstract

Synthetic analogues of the marine-derived class of natural products phloeodictines have been prepared and exhibited potent in vitro fungicidal activities against a broad array of Fungal pathogens including drug resistant strains. The 6-hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium structural moiety with a C12 to C16 aliphatic side chain at C-6 has been shown to be the Antifungal pharmacophore and may serve as a new Antifungal template for further lead optimization.