Neuraminidase inhibitory terpenes from endophytic Cochliobolus sp

  • J Asian Nat Prod Res. 2011 Aug;13(8):761-4. doi: 10.1080/10286020.2011.585608.
Gao-Fei Zhang  1 ,  Zhi-Kai Guo ,  Wei Wang ,  Jiang-Tao Cui ,  Ren-Xiang Tan ,  Hui-Ming Ge
Affiliations
  • 1. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing, China.
PMID: 21751846 DOI: 10.1080/10286020.2011.585608
Abstract

The chemical study of endophytic fungus of Cochliobolus led to the isolation of 10 terpenes (1-10), including one new compound named isocochlioquinone B (1). Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. Compounds 5-7 showed significant neuraminidase inhibitory activity with IC(50) values of 0.79-1.75 μM.

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