Monanchocidins B-E: polycyclic guanidine alkaloids with potent antileukemic activities from the sponge Monanchora pulchra

  • J Nat Prod. 2011 Sep 23;74(9):1952-8. doi: 10.1021/np200452m.
Tatyana N Makarieva  1 ,  Ksenya M Tabakmaher ,  Alla G Guzii ,  Vladimir A Denisenko ,  Pavel S Dmitrenok ,  Larisa K Shubina ,  Alexandra S Kuzmich ,  Hyi-Seung Lee ,  Valentin A Stonik
Affiliations
  • 1. Laboratory of MaNaPro Chemistry, Pacific Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 690022 Vladivostok-22, Russian Federation. [email protected]
PMID: 21848268 DOI: 10.1021/np200452m
Abstract

New unusual polycyclic guanidine Alkaloids monanchocidins B-E (2-5) along with monanchocidin A (1), which we recently described, were isolated from the Far-Eastern marine Sponge Monanchora pulchra. Their structures were established using spectroscopic data and chemical transformations. Compounds 1-5 show potent cytotoxic activities against HL-60 human leukemia cells with IC50 values of 540, 200, 110, 830, and 650 nM, respectively.