Synthesis and evaluation of compounds that induce readthrough of premature termination codons

  • Bioorg Med Chem Lett. 2011 Oct 1;21(19):5842-8. doi: 10.1016/j.bmcl.2011.07.107.
Michael E Jung  1 ,  Jin-Mo Ku ,  Liutao Du ,  Hailiang Hu ,  Richard A Gatti
Affiliations
  • 1. Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Ave., Los Angeles, CA 90095, United States. [email protected]
PMID: 21873052 DOI: 10.1016/j.bmcl.2011.07.107
Abstract

A structure-activity relationship (SAR) study was carried out to identify novel, small molecular weight compounds which induce readthrough of premature termination codons. In particular, analogs of RTC13, 1, were evaluated. In addition, hypothesizing that these compounds exhibit their activity by binding to the ribosome, we prepared the hybrid analogs 13 containing pyrimidine Bases and these also showed good readthrough activity.

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