Design, synthesis and biological evaluation of substituted 11H-benzo[a]carbazole-5-carboxamides as novel antitumor agents

  • Eur J Med Chem. 2011 Dec;46(12):5878-84. doi: 10.1016/j.ejmech.2011.09.050.
Yu-Qin Wang  1 ,  Xiao-Hua Li ,  Qian He ,  Yi Chen ,  Yu-Yuan Xie ,  Jian Ding ,  Ze-Hong Miao ,  Chun-Hao Yang
Affiliations
  • 1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, 555 Zu Chong Zhi Road, Shanghai 201203, PR China.
PMID: 22000922 DOI: 10.1016/j.ejmech.2011.09.050
Abstract

A series of novel 11H-benzo[a]carbazole-5-carboxamide derivatives were designed, synthesized and evaluated for their antitumor activity against human Cancer A549 and HCT-116 cell lines. Most of the compounds showed potent antitumor activities, and compound 8 displayed remarkable in vitro and in vivo Anticancer activity comparable to that of amonafide.