8-Substituted 5-[(aminoalkyl)amino]-6H-v-triazolo[4,5,1-de]acridin-6-ones as potential antineoplastic agents. Synthesis and biological activity

  • J Med Chem. 1990 Oct;33(10):2852-6. doi: 10.1021/jm00172a028.
W M Cholody  1 ,  S Martelli ,  J Konopa
Affiliations
  • 1. Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland.
PMID: 2213837 DOI: 10.1021/jm00172a028
Abstract

A series of 8-substituted 5-[(aminoalkyl)amino]-6H-v-triazolo[4,5,1-de]acridin-6-ones (2), structurally related to the imidazoacridinones (1), was synthesized and tested for cytotoxic and antineoplastic activity. Preliminary biological results indicated that the 8-OH derivatives possess the highest antitumor activity. No relationship has been found between the nature of the C-8 substituent and antitumor activity.