Hypoxylonols C-F, benzo[j]fluoranthenes from Hypoxylon truncatum

  • J Nat Prod. 2012 Jan 27;75(1):22-5. doi: 10.1021/np2004193.
Miyuki Fukai  1 ,  Mariko Tsukada ,  Kazuhiko Miki ,  Toshihiro Suzuki ,  Takashi Sugita ,  Kaoru Kinoshita ,  Kunio Takahashi ,  Motoo Shiro ,  Kiyotaka Koyama
Affiliations
  • 1. Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan.
PMID: 22148396 DOI: 10.1021/np2004193
Abstract

Four novel benzo[j]fluoranthene derivatives, hypoxylonols C (3), D (4), E (5), and F (6), have been isolated from the mushroom Hypoxylon truncatum, together with two known benzo[j]fluoranthene derivatives, hypoxylonols A (1) and B (2). The structures were established by analysis of NMR spectroscopic data and X-ray diffraction data. Compounds 4 and 5 showed antiproliferative activity against HUVECs (human umbilical vein endothelial cells) and HUAECs (human umbilical artery endothelial cells).