Melodinines M-U, cytotoxic alkaloids from Melodinus suaveolens

  • J Nat Prod. 2012 Feb 24;75(2):220-4. doi: 10.1021/np2009169.
Ya-Ping Liu  1 ,  Yan Li ,  Xiang-Hai Cai ,  Xing-Yao Li ,  Ling-Mei Kong ,  Gui-Guang Cheng ,  Xiao-Dong Luo
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
PMID: 22260257 DOI: 10.1021/np2009169
Abstract

Nine new Alkaloids, melodinines M-U (1-9), and 11 known Alkaloids were isolated from Melodinus suaveolens. The new structures were elucidated by extensive NMR and mass spectroscopic analyses and comparison to known compounds. All compounds were evaluated for their cytotoxicity against five human Cancer cell lines. Compounds 6, 11, and 16 showed significant cytotoxicity.