Cytotoxic phloroglucinols from the leaves of Myrtus communis

  • J Nat Prod. 2012 Feb 24;75(2):225-9. doi: 10.1021/np2009219.
Filippo Cottiglia  1 ,  Laura Casu ,  Marco Leonti ,  Pierluigi Caboni ,  Costantino Floris ,  Bernardetta Busonera ,  Pamela Farci ,  Aicha Ouhtit ,  Giuseppina Sanna
Affiliations
  • 1. Dipartimento Farmaco Chimico Tecnologico, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy. [email protected]
PMID: 22276775 DOI: 10.1021/np2009219
Abstract

Bioactivity-guided fractionation of a dichloromethane extract of the leaves of Myrtus communis led to the isolation of phloroglucinol derivatives. The structures of the new myrtucommulones J, K, and L (1-3) and the previously known myrtucommulone A (4) were elucidated on the basis of extensive 1D and 2D NMR experiments as well as high-resolutionmass spectrometry. Myrtucommulone J was obtained as a tautomeric pair (1/1a). The compounds were tested in vitro for their cytotoxic and Antibacterial activities.