Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide

  • Bioorg Med Chem Lett. 2012 Feb 15;22(4):1660-3. doi: 10.1016/j.bmcl.2011.12.114.
Junju Xu  1 ,  Changjiu Ji ,  Yumei Zhang ,  Jia Su ,  Yan Li ,  Ninghua Tan
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China.
PMID: 22277277 DOI: 10.1016/j.bmcl.2011.12.114
Abstract

Sixteen eudesmane-type Sesquiterpenes including seven new compounds oxyphyllanene A-G (1-2 and 5-9) were isolated from the fruits of Alpinia oxyphylla. Among them, compounds 1-2 are novel trinoreudesmane Sesquiterpenes, and 5 is a noreudesmane one. Their structures were established by spectroscopic analysis, including 2D-NMR techniques. Inhibitory activity of compounds 3-8 and 10-16 were tested against nitric oxide production in LPS and IFN-γ-induced RAW 264.7 murine macrophages, and their IC(50) values ranged from 9.85 to 13.95 μg/ml.