2,5-diketopiperazines from the marine-derived fungus Aspergillus fumigatus YK-7

  • Chem Biodivers. 2012 Feb;9(2):385-93. doi: 10.1002/cbdv.201100061.
Yu Wang  1 ,  Zhan-Lin Li ,  Jiao Bai ,  Li-Min Zhang ,  Xin Wu ,  Lin Zhang ,  Yue-Hu Pei ,  Yong-Kui Jing ,  Hui-Ming Hua
Affiliations
  • 1. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
PMID: 22344914 DOI: 10.1002/cbdv.201100061
Abstract

Five new diketopiperazines, prenylcyclotryprostatin B (1), 20-hydroxycyclotryprostatin B (2), 9-hydroxyfumitremorgin C (3), 6-hydroxytryprostatin B (4), and spirogliotoxin (5), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with nine known compounds, 6-14. Their structures were elucidated by spectroscopic methods, and their antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate Cancer PC-3 cell lines were assessed in vitro. Compounds 10, 12, and 13 exhibited significant cell growth-inhibitory activities against U937 cell line, with the IC(50) values of 1.8, 0.2, and 0.5 μM, respectively.

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