Bioactive carbazole alkaloids from Clausena wallichii roots

  • J Nat Prod. 2012 Apr 27;75(4):741-6. doi: 10.1021/np3000365.
Wisanu Maneerat  1 ,  Thunwadee Ritthiwigrom ,  Sarot Cheenpracha ,  Trinop Promgool ,  Kulsiri Yossathera ,  Suwanna Deachathai ,  Wong Phakhodee ,  Surat Laphookhieo
Affiliations
  • 1. Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand.
PMID: 22482432 DOI: 10.1021/np3000365
Abstract

Four new Carbazole Alkaloids, clausenawallines C-F (1-4), along with 18 known compounds (5-22) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant Antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus TISTR 1466 with MIC values in the range 4-16 μg/mL, whereas compound 4 showed the highest cytotoxicity against oral cavity Cancer (KB) and small-cell lung Cancer (NCI-H187) with IC(50) values of 10.2 and 4.5 μM, respectively.