Synthesis and antitumor activity of formononetin nitrogen mustard derivatives
- Eur J Med Chem. 2012 Aug:54:175-87. doi: 10.1016/j.ejmech.2012.04.039.
Affiliations
- 1. School of Pharmaceutical Engineering & Life Science, Changzhou University, 1 Gehu Road, Changzhou, Jiangsu 213164, PR China.
PMID: 22633834
DOI: 10.1016/j.ejmech.2012.04.039
Abstract
A series of formononetin nitrogen mustard derivatives were synthesized and evaluated in vitro for their cytotoxicity against five Cancer cell lines (SH-SY5Y, HCT-116, DU-145, Hela and SGC-7901). The pharmacological results showed that many of the new derivatives displayed more potent cytotoxicity than alkeran. Furthermore, compounds 6d and 6n could induce cell cycle arrest at G2/M phase and cell Apoptosis.