Semi-synthesis and bio-evaluation of polybrominated diphenyl ethers from the sponge Dysidea herbacea

  • Bioorg Med Chem Lett. 2012 Jul 15;22(14):4900-6. doi: 10.1016/j.bmcl.2012.04.133.
T Srikanth Reddy  1 ,  N Suryakiran ,  M Narasimhulu ,  D Ramesh ,  K Chinni Mahesh ,  A Sai Krishna ,  P Kavitha ,  J Venkateswara Rao ,  Y Venkateswarlu
Affiliations
  • 1. Natural Products Chemistry Division, Natural Products Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India.
PMID: 22704923 DOI: 10.1016/j.bmcl.2012.04.133
Abstract

The Sponge Dysidea herbacea was collected from the Mandapam Coast, Tamilnadu, India. Isolated gram quantities of hydroxylated polybrominated diphenyl ether (HO-PBDE) and semi-synthesized a series of new PBDEs derivatives and tested them for Antibacterial and cytotoxic activities.