Eco-friendly synthesis and biological evaluation of substituted pyrano[2,3-c]pyrazoles

  • Bioorg Med Chem Lett. 2012 Aug 15;22(16):5272-8. doi: 10.1016/j.bmcl.2012.06.055.
Santhosh Reddy Mandha  1 ,  Sravanthi Siliveri ,  Manjula Alla ,  Vittal Rao Bommena ,  Madhava Reddy Bommineni ,  Sridhar Balasubramanian
Affiliations
  • 1. Crop Protection Chemicals Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India.
PMID: 22818081 DOI: 10.1016/j.bmcl.2012.06.055
Abstract

An ecofriendly green approach for synthesis of substituted pyrano[2,3-c]pyrazoles has been developed via a multicomponent one pot approach in aqueous ethanol medium under totally non-catalytic conditions. The synthesized compounds were evaluated for their Antibacterial, anti-inflammatory and cytotoxic activities.