Antibacterial spirobisnaphthalenes from the North American cup fungus Urnula craterium

  • J Nat Prod. 2012 Sep 28;75(9):1534-8. doi: 10.1021/np300221a.
Xue-Ting Liu  1 ,  William R Schwan ,  Thomas J Volk ,  Marc Rott ,  Miaomiao Liu ,  Pei Huang ,  Zhong Liu ,  Ying Wang ,  Nicholas C Zitomer ,  Cassandra Sleger ,  Scott Hartsel ,  Aaron Monte ,  Lixin Zhang
Affiliations
  • 1. Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100190, People's Republic of China.
PMID: 22934636 DOI: 10.1021/np300221a
Abstract

Urnucratins A-C (1-3), which possess an unusual bisnaphthospiroether skeleton with one oxygen bridge and one C-C bridge and represent a new subclass of bisnaphthalenes, were isolated from the North American cup fungus Urnula craterium. Their structures, including absolute configurations, were determined by means of HRMS, NMR, and quantum chemical CD calculations. Urnucratin A (1) was found to be active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and Streptococcus pyogenes with MIC values of 2, 1, and 0.5 μg/mL, respectively.