Tormentic acid derivatives: synthesis and apoptotic activity

  • Eur J Med Chem. 2012 Oct:56:237-45. doi: 10.1016/j.ejmech.2012.08.032.
René Csuk  1 ,  Bianka Siewert ,  Christian Dressel ,  Renate Schäfer
Affiliations
  • 1. Bereich Organische Chemie, Martin-Luther Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany. [email protected]
PMID: 22995818 DOI: 10.1016/j.ejmech.2012.08.032
Abstract

Several derivatives of tormentic acid have been prepared and tested for their antitumor activity. The dichloroacetate 14 is an excellent antitumor active agent acting by an apoptose inducing pathway as demonstrated by OA/PI staining, DNA laddering experiments as well as by an annexin V binding assay.