Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells
- Biotechnol Lett. 2012 Dec;34(12):2213-21. doi: 10.1007/s10529-012-1036-y.
- 1. Department of Biotechnology, Graduate School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea.
A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed Cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in Cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.
-
Cat. No.Product NameDescriptionTargetResearch Area
-
target: LXRResearch Areas: Cardiovascular Disease