Phenolic compounds from Caesalpinia sappan heartwood and their anti-inflammatory activity

  • J Nat Prod. 2012 Dec 28;75(12):2069-75. doi: 10.1021/np3003673.
To Dao Cuong  1 ,  Tran Manh Hung ,  Jin Cheol Kim ,  Eun Hee Kim ,  Mi Hee Woo ,  Jae Sue Choi ,  Jeong Hyung Lee ,  Byung Sun Min
Affiliations
  • 1. College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk 712-702, Korea.
PMID: 23234407 DOI: 10.1021/np3003673
Abstract

Four new phenolic compounds, caesalpiniaphenols A-D (1-4), together with eight known compounds were isolated from Caesalpinia sappan heartwood. The chemical structures were established mainly by NMR, MS, ECD, and Mosher's method. Compounds 4, 5, and 7 showed weak inhibitory activity against the LPS-induced NO production in macrophage RAW264.7 cells with IC(50) values of 12.2, 3.5, and 5.7 μM, respectively.