A new monoterpenoid oxindole alkaloid from Hamelia patens micropropagated plantlets

  • Nat Prod Commun. 2012 Nov;7(11):1441-4.
David Paniagua-Vega  1 ,  Carlos M Cerda-García-Rojas ,  Teresa Ponce-Noyola ,  Ana C Ramos-Valdivia
Affiliations
  • 1. Departamento de Biotecnología y Bioingeniería, Centro de Investigación y de Estudios Avanzados del Instituto Nacional, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, 07360 Mexico D. F., Mexico.
PMID: 23285803
Abstract

Chemical studies on Hamelia patens (Rubiaceae) micropropagated plantlets allowed production of a new monoterpenoid oxindole alkaloid, named (-)-hameline (7), together with eight known Alkaloids, tetrahydroalstonine (1), aricine (2), pteropodine (3), isopteropodine (4), uncarine F (5), speciophylline (6), palmirine (8), and rumberine (9). The structure of the new alkaloid was assigned on the basis of 1D and 2D NMR spectroscopy, mass spectrometry, and molecular modeling.

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