Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent

  • Eur J Med Chem. 2013 Feb:60:120-7. doi: 10.1016/j.ejmech.2012.11.044.
Koneni V Sashidhara  1 ,  Srinivasa Rao Avula ,  Komal Sharma ,  Gopala Reddy Palnati ,  Surendar Reddy Bathula
Affiliations
  • 1. Department of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India. [email protected]
PMID: 23287057 DOI: 10.1016/j.ejmech.2012.11.044
Abstract

Development of new, targeted antibreast Cancer drug which can treat both the hormone receptor (positive and negative) breast cancers is a very challenging task. The concept of molecular hybridization led us to discover a novel class of coumarin-monastrol hybrid, as a novel breast Cancer agent which selectively induce Apoptosis in both primary and metastatic breast Cancer cell lines.