New PAH derivatives functionalized by cyclic nitrone framework: synthetic design, anti-proliferative activity and interaction with DNA

  • Bioorg Med Chem. 2013 Mar 1;21(5):1078-81. doi: 10.1016/j.bmc.2013.01.004.
Marian Buchlovič  1 ,  Zdeněk Kříž ,  Ctirad Hofr ,  Milan Potáček
Affiliations
  • 1. Department of Chemistry, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.
PMID: 23352483 DOI: 10.1016/j.bmc.2013.01.004
Abstract

Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. Incorporation of cyclic nitrone framework into the structure of PAHs was studied with respect to their anti-proliferative activities and interaction with double stranded DNA. Theoretical docking studies and UV titration methods were used for preliminary evaluation of binding of new PAH derivatives to DNA structure.