(M)- and (P)-bicelaphanol A, dimeric trinorditerpenes with promising neuroprotective activity from Celastrus orbiculatus

  • J Nat Prod. 2013 Apr 26;76(4):745-9. doi: 10.1021/np3008182.
Luo-Yi Wang  1 ,  Jian Wu ,  Zhuo Yang ,  Xu-Jie Wang ,  Yan Fu ,  Shuang-Zhu Liu ,  Hong-Min Wang ,  Wei-Liang Zhu ,  Hai-Yan Zhang ,  Wei-Min Zhao
Affiliations
  • 1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
PMID: 23421714 DOI: 10.1021/np3008182
Abstract

(M)-Bicelaphanol A (1) and (P)-bicelaphanol A (2), two unprecedented dimeric trinorditerpenes existing as atropisomers, together with their monomer celaphanol A (3), were isolated from the root bark of Celastrus orbiculatus. The structures and absolute configurations of 1 and 2 were determined by spectroscopic and single-crystal X-ray diffraction analyses. Compound 1 exhibited a significant in vitro neuroprotective effect against a hydrogen peroxide-induced cell viability decrease in PC12 cells at 1 μM, while compounds 2 and 3 showed such effects at 10 μM.

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