Novel microbial transformation of desacetylcinobufagin by Fusarium avenaceum AS 3.4594

  • J Asian Nat Prod Res. 2013;15(3):294-9. doi: 10.1080/10286020.2013.763227.
Zhi-Tu Zhu  1 ,  Sha Den ,  Yan Wang ,  Yan-Yan Zhao ,  Li Wang ,  Hui-Rang Chen ,  Dan Liu
Affiliations
  • 1. The First Affiliated Hospital of Liaoning Medical University, Jinzhou 120001, China.
PMID: 23421737 DOI: 10.1080/10286020.2013.763227
Abstract

In this paper, the microbial transformation of desacetylcinobufagin (1) by Fusarium avenaceum AS 3.4594 was investigated, and four metabolites were isolated and characterized as 3-keton-desacetylcinobufagin (2), 3-epi-desacetylcinobufagin (3), bufadienolide A (4), and 15β,16α-dihydroxyl-17βH-bufalin (5), respectively. Among them, 4 and 5 are new compounds. The cytotoxicities of transformed products (2-5) against Hela cells were also investigated.

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