Polycyclic hybrid isoprenoids from a reed rhizosphere soil derived Streptomyces sp. CHQ-64

  • J Nat Prod. 2013 Apr 26;76(4):759-63. doi: 10.1021/np3008864.
Qian Che  1 ,  Tianjiao Zhu ,  Robert A Keyzers ,  Xiaofang Liu ,  Jing Li ,  Qianqun Gu ,  Dehai Li
Affiliations
  • 1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
PMID: 23547884 DOI: 10.1021/np3008864
Abstract

Two new hybrid isoprenoids, named indotertine B (2) and drimentine H (3), along with the known analogue drimentine C (4), were isolated from the reed rhizosphere soil derived actinomycete Streptomyces sp. CHQ-64. The structures of these compounds, including absolute configurations, were elucidated by extensive NMR, MS, and CD analyses. Indotertine B (2) exists as a pair of rotamers about the N-C(O) bond with a 2:1 ratio and displays activities against HCT-8 and A549 tumor cell lines with IC50 values of 6.96 and 4.88 μM, respectively.