Xanthoquinodins from the endolichenic fungal strain Chaetomium elatum

  • J Nat Prod. 2013 Apr 26;76(4):702-9. doi: 10.1021/np400041y.
Guo-Dong Chen  1 ,  Ying Chen ,  Hao Gao ,  Li-Qing Shen ,  Yang Wu ,  Xiao-Xia Li ,  Yan Li ,  Liang-Dong Guo ,  Ying-Zhou Cen ,  Xin-Sheng Yao
Affiliations
  • 1. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
PMID: 23586920 DOI: 10.1021/np400041y
Abstract

Five new xanthoquinodins, A4-A6 (1-3), B4 (4), and B5 (5), were isolated from the crude extract of the endolichenic Fungal strain Chaetomium elatum (No. 63-10-3-1), along with three known xanthoquinodins, A1-A3 (6-8). Their structures were determined by detailed spectroscopic analysis and comparison of the NMR data with those of the closely related compounds previously reported. The absolute configuration of 1 was established by X-ray crystallographic analysis and ECD calculation. The cytotoxic activity of all compounds was tested against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human Cancer cell lines.