Andrographidine G, a new flavone glucoside from Andrographis paniculata

  • Nat Prod Commun. 2013 Mar;8(3):333-4.
Swarna D Hapuarachchi  1 ,  Zulfiqar Ali ,  Naohito Abe ,  Suresh T Sugandhika ,  Senerath T P Sandun ,  Ikhlas A Khan
Affiliations
  • 1. National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
PMID: 23678804
Abstract

A new flavone glucoside, andrographidine G (1), was isolated from Andrographis paniculata together with 13 known compounds, including Flavonoids, Diterpenoids, and Iridoids. The structure of 1 was established by spectroscopic and spectrometric techniques, including HR-ESI-TOF-MS, 1D and 2D NMR, and chemical methods. The known compounds were identified as andrographidine A (2), (2R)-5-hydroxy-7,8-dimethoxyflavanone-5-O-beta-D-glucopyranoside (3), acanthoside B (4), neoandrographiside (5), andropanoside (6), andrographiside (7), andrographolide (8), 14-deoxy-11,12-didehydroandrographiside (9), 14-deoxy-11,12-didehydroandrographolide (10), procumbide (11), procumboside (12), 6-epi-8-O-acetylharpagide (13), and curvifloruside F (14).

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