A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity

  • Bioorg Med Chem. 2013 Jul 1;21(13):3695-701. doi: 10.1016/j.bmc.2013.04.031.
Claudio Battilocchio  1 ,  Giovanna Poce ,  Salvatore Alfonso ,  Giulio Cesare Porretta ,  Sara Consalvi ,  Lidia Sautebin ,  Simona Pace ,  Antonietta Rossi ,  Carla Ghelardini ,  Lorenzo Di Cesare Mannelli ,  Silvia Schenone ,  Antonio Giordani ,  Luigia Di Francesco ,  Paola Patrignani ,  Mariangela Biava
Affiliations
  • 1. Dipartimento di Studi di Chimica e Tecnologie del Farmaco, Università Sapienza, Piazzale Aldo Moro 5, I-00185 Roma, Italy.
PMID: 23680444 DOI: 10.1016/j.bmc.2013.04.031
Abstract

We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules.