Antiviral alkaloids produced by the mangrove-derived fungus Cladosporium sp. PJX-41

  • J Nat Prod. 2013 Jun 28;76(6):1133-40. doi: 10.1021/np400200k.
Jixing Peng  1 ,  Tao Lin ,  Wei Wang ,  Zhihong Xin ,  Tianjiao Zhu ,  Qianqun Gu ,  Dehai Li
Affiliations
  • 1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
PMID: 23758051 DOI: 10.1021/np400200k
Abstract

Six new Indole Alkaloids including five new glyantrypine derivatives (1, 2a, 2b, 3, 4) and a new pyrazinoquinazoline derivative (5), together with eight known Alkaloids (6-13), were isolated from the culture of the mangrove-derived fungus Cladosporium sp. PJX-41. Their structures were elucidated primarily by spectroscopic and physical data. The absolute configurations of compounds 1-9 were established on the basis of CD, NOESY data, and single-crystal X-ray diffraction analysis. Compounds 2b, 5, 7-9, and 11 exhibited significant activities against Influenza Virus A (H1N1), with IC50 values of 82-89 μM.