Biochemical effects of luxabendazole on Trichinella spiralis

  • Parasitol Res. 1990;76(6):518-20. doi: 10.1007/BF00931057.
A Criado-Fornelio  1 ,  C de Armas-Serra ,  A Jimenez-Gonzalez ,  N Casado-Escribano ,  F Rodriguez-Caabeiro
Affiliations
  • 1. Parasitology and Microbiology Department, Faculty of Pharmacy, University of Alcalá de Henares, Madrid, Spain.
PMID: 2381894 DOI: 10.1007/BF00931057
Abstract

Biochemical changes produced by luxabendazole in muscle-stage Trichinella spiralis larvae consisted of a decrease in free glucose and glycogen levels (46.71% and 35.66%, respectively) after in vivo treatment, slight in vitro inhibition of fumarate reductase activity (24.15%) and, finally, inhibition of [3H]-colchicine-tubulin binding, which was found to be of a competitive nature, with an inhibition constant (Ki) of 0.9 x 10(-7) M. In a parallel study, luxabendazole did not appear to be inhibitory to [3H]-colchicine binding to pig-brain tubulin.

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