Trichomycin B, a polyene macrolide from Streptomyces

  • J Antibiot (Tokyo). 1990 Jul;43(7):778-82. doi: 10.7164/antibiotics.43.778.
T Komori  1
Affiliations
  • 1. Research and Technology Group, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
PMID: 2387771 DOI: 10.7164/antibiotics.43.778
Abstract

Two polyene Macrolide, trichomycins A and B, were compared by physico-chemical and microbiological methods. The two Antibiotics were found to have the same molecular formula, C58H84N2O18 (MW 1,096), by elemental analysis and FAB-MS. However, 1H and 13C NMR spectrometry studies indicated that the hydroxyl at C-5 of trichomycin A located on C-9 in trichomycin B. Trichomycin B possessed lower activities against fungi and yeasts than those of trichomycin A.

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