Synthesis and SAR studies of marine natural products ma'edamines A, B and their analogues

  • Bioorg Med Chem Lett. 2013 Sep 15;23(18):5135-9. doi: 10.1016/j.bmcl.2013.07.017.
Sanjay Saha  1 ,  Ch Venkata Ramana Reddy ,  Shili Xu ,  Saranya Sankar ,  Nouri Neamati ,  Balaram Patro
Affiliations
  • 1. GVK Biosciences Private Limited, Medicinal Chemistry Division, 28A, IDA, Nacharam, Hyderabad 500076, India.
PMID: 23927972 DOI: 10.1016/j.bmcl.2013.07.017
Abstract

The synthesis of several analogues of ma'edamines A and B are reported. The synthesized compounds were tested on hormone receptor positive and HER2 positive breast Cancer cell lines, by MTT assay. MED-114, 115, 117, 119, 120, 124, 128 and 131 were found to be equally active as Lapatinib on HER2 +ve cell line SKBR3.

Keywords
Anticancer; Antiproliferative activity; Breast cancer; HER2; Marine natural products.