Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives

  • Bioorg Med Chem Lett. 2013 Oct 1;23(19):5264-6. doi: 10.1016/j.bmcl.2013.08.021.
Theerachart Leepasert  1 ,  Manochehr Shahabi ,  Karem Shanab ,  Eva Schirmer ,  Wolfgang Holzer ,  Helmut Spreitzer ,  Babette Aicher ,  Gilbert Müller ,  Eckhard Günther
Affiliations
  • 1. Department of Drug and Natural Product Synthesis, University of Vienna, Vienna, Austria.
PMID: 23988351 DOI: 10.1016/j.bmcl.2013.08.021
Abstract

A new series of substituted tri-/tetraazabenzo[3,2-a]fluorene-5,6-diones and their corresponding oxime derivatives have been synthesized and spectroscopically characterized. The antiproliferative activities of all compounds were evaluated on at least three different cell lines.

Keywords
Anticancer compounds.