Three new phenolics and other constituents from the seeds of Lithocarpus pachylepis

  • Molecules. 2013 Aug 28;18(9):10397-403. doi: 10.3390/molecules180910397.
Yong Xie  1 ,  Guoxu Ma ,  Hua Wei ,  Jingquan Yuan ,  Haifeng Wu ,  Xiaolei Zhou ,  Junshan Yang ,  Xudong Xu
Affiliations
  • 1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
PMID: 23989685 DOI: 10.3390/molecules180910397
Abstract

Twelve phenolics, including the three new compounds balanophonin C (1), balanophonin D (2), balanophonin E (3), were isolated from the seeds of Lithocarpus pachylepis. Their structures were elucidated by various spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). Compounds 1-9 were evaluated for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 and showed moderate inhibitory activities, with IC₅₀ values ranging from 10.9 to 34.7 μM.

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