Cytotoxic deoxybenzoins and diphenylethylenes from Arundina graminifolia

  • J Nat Prod. 2013 Oct 25;76(10):1854-9. doi: 10.1021/np400379u.
Qiu-Fen Hu  1 ,  Bin Zhou ,  Yan-Qing Ye ,  Zhi-Yong Jiang ,  Xiang-Zhong Huang ,  Yin-Ke Li ,  Gang Du ,  Guang-Yu Yang ,  Xue-Mei Gao
Affiliations
  • 1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities , Kunming 650031, Yunnan, People's Republic of China.
PMID: 24063582 DOI: 10.1021/np400379u
Abstract

Eight new C-4-alkylated deoxybenzoins (1-8), three new diphenylethylenes (9-11), and five known diphenylethylenes were isolated from Arundina graminifolia. The structures of 1-11 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 9-11 are the first naturally occurring diphenylethylenes possessing a hydroxyethyl unit. Compounds 1-11 were evaluated for cytotoxicity against five human tumor cell lines. Compounds 4, 5, and 9-11 showed significant cytotoxicity against five Cancer cell lines, with IC50 values ranging from 1.8 to 8.7 μM.