Extending the record of bis-γ-pyrone polypropionates from marine pulmonate mollusks

  • J Nat Prod. 2013 Nov 22;76(11):2065-73. doi: 10.1021/np400483c.
Marianna Carbone  1 ,  M Letizia Ciavatta ,  Jian-Rong Wang ,  Ilaria Cirillo ,  Véronique Mathieu ,  Robert Kiss ,  Ernesto Mollo ,  Yue-Wei Guo ,  Margherita Gavagnin
Affiliations
  • 1. Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB) , Via Campi Flegrei, 34, 80078 Pozzuoli, Naples, Italy.
PMID: 24180210 DOI: 10.1021/np400483c
Abstract

The isolation and structure elucidation of 10 unreported polypropionate metabolites (compounds 6-15), structurally related to either ilikonapyrone (1) or onchidione (3), from two onchidiid pulmonate mollusk species are discussed. Structure elucidation was achieved by NMR spectroscopy and chemical correlation with model compounds. Evaluation of in vitro growth-inhibitory properties in human Cancer cells was also carried out on some of the isolated polypropionates including previously reported onchidione metabolites.