Bridged tricyclic sesquiterpenes from the tubercle nudibranch Phyllidia coelestis Bergh

  • J Nat Prod. 2013 Nov 22;76(11):2158-61. doi: 10.1021/np4007074.
Sunan Jaisamut  1 ,  Samran Prabpai ,  Chompoonuch Tancharoen ,  Supreeya Yuenyongsawad ,  Supa Hannongbua ,  Palangpon Kongsaeree ,  Anuchit Plubrukarn
Affiliations
  • 1. Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University , Hat-Yai, Songkhla 90112, Thailand.
PMID: 24200393 DOI: 10.1021/np4007074
Abstract

A new sesquiterpene, 1-formamido-10(1→2)-abeopupukeanane (1), was isolated from the tubercle nudibranch Phyllidia coelestis Bergh, along with 2-formamidopupukeanane (2), which is reported here as a natural product for the first time. A rearrangement pathway toward the unprecedented tricyclo[4.4.0.0(2,8)]decane skeleton is proposed. Both compounds showed antiproliferative activity when targeting HeLa, MCF-7, KB, and HT-29 Cancer cell lines in the range 0.05-10 μM.