Curcumin glucuronides: assessing the proliferative activity against human cell lines

  • Bioorg Med Chem. 2014 Jan 1;22(1):435-9. doi: 10.1016/j.bmc.2013.11.006.
Ashutosh Pal  1 ,  Bokyung Sung  1 ,  Basvoju A Bhanu Prasad  1 ,  Paul T Schuber Jr  1 ,  Sahdeo Prasad  1 ,  Bharat B Aggarwal  1 ,  William G Bornmann  2
Affiliations
  • 1. Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
  • 2. Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: [email protected].
PMID: 24280069 DOI: 10.1016/j.bmc.2013.11.006
Abstract

A gram scale synthesis of the glucuronide metabolites of curcumin were completed in four steps. The newly synthesized curcumin glucuronide compounds 2 and 3 along with curcumin 1 were tested and their anti-proliferative effects against KBM-5, Jurkat cell, U266, and A549 cell lines were reported. Biological data revealed that as much as 1 μM curcumin 1 exhibited Anticancer activity and almost 100% cell kill was noted at 10 μM on two out of four cell lines; while curcumin mono-glucuronide 2 as well as di-glucuronide 3 displayed no suppression of cell proliferation.

Keywords
Curcumin; Curcumin di-glucuronides; Curcumin mono-glucuronide; ISDDQQPRTHCEGT-XANUIUACSA-N; JCAFLHUESYYNFH-NMQQATKUSA-N; ZIUSSTSXXLLKKK-KOBPDPAPSA-N.