Kadcotriones A-C: tricyclic triterpenoids from Kadsura coccinea

  • J Nat Prod. 2013 Dec 27;76(12):2350-4. doi: 10.1021/np400546z.
Cheng-Qin Liang  1 ,  Yi-Ming Shi ,  Xing-Yao Li ,  Rong-Hua Luo ,  Yan Li ,  Yong-Tang Zheng ,  Hong-Bin Zhang ,  Wei-Lie Xiao ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
PMID: 24299567 DOI: 10.1021/np400546z
Abstract

Three new triterpenoids, kadcotriones A-C (1-3), together with the biogenetically related lanostane-type triterpenoid (4), were isolated from Kadsura coccinea. Compound 1 features a 12,14β-dimethyl 6/6/6-fused tricyclic skeleton, while 2 and 3 are characterized by a 6/6/5-ring system. Their structures were determined by NMR and electronic circular dichroism spectroscopic methods. Compounds 2 and 4 exhibited anti-HIV-1 activities with EC50 values of 30.29 and 54.81 μM, respectively.