Potent phosphatidylinositol 3-kinase inhibitors and their biology
- Curr Drug Discov Technol. 2014 Jun;11(2):113-26. doi: 10.2174/1570163810666131229130207.
Affiliations
- 1. Department of Chemistry, Motilal Nehru College, University of Delhi, Delhi-110021, India. [email protected].
PMID: 24372076
DOI: 10.2174/1570163810666131229130207
Abstract
The Phosphoinositide 3-kinase (PI3K) is an important regulator of intracellular signalling pathways, like cell proliferation, migration, survival, and angiogenesis upon activation by growth factor or receptors. The PI3k's pathway is frequently up-regulated in human cancers, thus inhibition of PI3k's is a promising approach for Cancer therapy. Many potent PI3k's inhibitors have been reported so far and few of them are in clinical trial like GDC-0941, BGT-226, AZD-6482 and Others are natural products etc.