RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening

  • J Antibiot (Tokyo). 2014 Apr;67(4):323-9. doi: 10.1038/ja.2013.144.
Chung Liang Lim  1 ,  Toshihiko Nogawa  2 ,  Masakazu Uramoto  3 ,  Akiko Okano  2 ,  Yayoi Hongo  4 ,  Takemichi Nakamura  4 ,  Hiroyuki Koshino  4 ,  Shunji Takahashi  5 ,  Darah Ibrahim  6 ,  Hiroyuki Osada  5
Affiliations
  • 1. 1] Antibiotics Laboratory, RIKEN, Saitama, Japan [2] Industrial Biotechnology Research Laboratory, School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia.
  • 2. RIKEN Center for Sustainable Research Science, Saitama, Japan.
  • 3. Antibiotics Laboratory, RIKEN, Saitama, Japan.
  • 4. RIKEN Global Research Cluster, Saitama, Japan.
  • 5. 1] Antibiotics Laboratory, RIKEN, Saitama, Japan [2] RIKEN Center for Sustainable Research Science, Saitama, Japan.
  • 6. Industrial Biotechnology Research Laboratory, School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia.
PMID: 24496142 DOI: 10.1038/ja.2013.144
Abstract

Two novel quinomycin derivatives, RK-1355A (1) and B (2), and one known quinomycin derivative, UK-63,598 (3), were isolated from a microbial metabolites fraction library of Streptomyces sp. RK88-1355 based on Natural Products Plot screening. The structural elucidation of 1 and 2 was established through two-dimensional NMR and mass spectrometric measurements. They belong to a class of quinomycin Antibiotics family having 3-hydroxyquinaldic acid and a sulfoxide moiety. They are the first examples for natural products as a quinoline type quinomycin having a sulfoxide on the intramolecular cross-linkage. They showed potent antiproliferative activities against various Cancer cell lines and they were also found to exhibit moderate Antibacterial activity.

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