A,D-seco-limonoids from the stems of Clausena emarginata

  • J Nat Prod. 2014 Apr 25;77(4):784-91. doi: 10.1021/np400797s.
Hong-Min Xia  1 ,  Chuang-Jun Li ,  Jing-Zhi Yang ,  Jie Ma ,  Xiao-Guang Chen ,  Dan Zhang ,  Li Li ,  Dong-Ming Zhang
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
PMID: 24593150 DOI: 10.1021/np400797s
Abstract

Twelve new A,D-seco-limonoids, clauemargines A-L (1-12), and three known analogues were isolated from the stems of Clausena emarginata. The absolute configurations of 1 and 5 were confirmed by X-ray crystallography and ECD spectroscopy, respectively. Compounds 1, 2, 8-10, and 13 showed moderate inhibitory effects on LPS-induced NO production (IC50 values<10 μM).