How Tets and cytoskeleton dynamics MET in reprogramming

  • Cell Stem Cell. 2014 Apr 3;14(4):417-8. doi: 10.1016/j.stem.2014.03.007.
Laurent David  1 ,  Calley L Hirsch  2
Affiliations
  • 1. INSERM, UMR 1064, 44093 Nantes Cedex 1, France; Faculté de Médecine, Université de Nantes, 44035 Nantes Cedex 1, France; iPSC Core Facility, SFR F. Bonamy, Université de Nantes, France. Electronic address: [email protected].
  • 2. Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada.
PMID: 24702989 DOI: 10.1016/j.stem.2014.03.007
Abstract

Two studies by Sakurai et al. (2014) and Hu et al. (2014) in this issue of Cell Stem Cell add a new level of understanding to the mesenchymal-to-epithelial transition taking place during reprogramming, showing how this morphological transformation is promoted by Tet Enzymes and blocked by kinase-dependent cytoskeletal organization.