Evaluation of molecules based on the electron donor-acceptor architecture as near-infrared β-amyloidal-targeting probes

  • Chem Commun (Camb). 2014 Oct 14;50(80):11875-8. doi: 10.1039/c4cc04907a.
Hualong Fu  1 ,  Mengchao Cui ,  Peiyu Tu ,  Ziwei Pan ,  Boli Liu
Affiliations
  • 1. Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China. [email protected].
PMID: 25156492 DOI: 10.1039/c4cc04907a
Abstract

A novel class of near-infrared molecules based on the donor-acceptor architecture were synthesized and evaluated as Aβ imaging probes. In vivo imaging studies suggested that MCAAD-3 could penetrate the blood-brain barrier and label Aβ plaques in the brains of transgenic mice. Computational studies could reproduce the experimental trends well.

Products