Differential effects of malotilate on 5-, 12- and 15-lipoxygenase in human ascites cells

  • Eur J Pharmacol. 1989 Jan 17;159(3):291-5. doi: 10.1016/0014-2999(89)90160-x.
F J Zijlstra  1 ,  J H Wilson ,  M A Vermeer ,  R J Ouwendijk ,  J E Vincent
Affiliations
  • 1. Department of Pharmacology, Erasmus University Rotterdam, The Netherlands.
PMID: 2537738 DOI: 10.1016/0014-2999(89)90160-x
Abstract

Macrophages isolated from fluids of patients with liver cirrhosis mainly generated the 5-lipoxygenase products leukotriene B4 and 5-monohydroxyeicosatetraenoic acid. The cyclooxygenase products 6-keto-PGF1 alpha and thromboxane B2 were the most important prostaglandin-like substances. Malotilate, an anti-fibrotic substance, selectively inhibited the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways were stimulated. The effects of malotilate on eicosanoid production differ from those of known Lipoxygenase inhibitors. Such differential effects have not been reported previously.

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