Cascade polyketide and polyene cyclizations: biomimetic total synthesis of hongoquercin B
- J Am Chem Soc. 2014 Dec 10;136(49):17013-5. doi: 10.1021/ja511534x.
Affiliations
- 1. Department of Chemistry, Imperial College London , London SW7 2AZ, England.
PMID: 25423048
DOI: 10.1021/ja511534x
Abstract
The total synthesis of hongoquercin B was carried out in 9 steps from trans,trans-farnesyl acetate using a palladium catalyzed decarboxylative π-farnesyl rearrangement of a diketo-dioxinone ester, aromatization and cationic diene-epoxide cyclization as key steps. This cascade tetracyclization simplifies the synthesis of terpenoid resorcylate natural products.
Products
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Cat. No.Product NameDescriptionTargetResearch Area
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Research Areas: Infection