Anti-inflammatory secoiridoid glycosides from Gentianella azurea

  • Bioorg Med Chem Lett. 2014 Nov 15;24(22):5260-4. doi: 10.1016/j.bmcl.2014.09.055.
Yu-jie Huang  1 ,  Hui Lu  1 ,  Xue-li Yu  1 ,  Wei-bing Song  1 ,  Shu-wei Zhang  1 ,  Lin-yin Fen  1 ,  Li-jiang Xuan  2
Affiliations
  • 1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
  • 2. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China. Electronic address: [email protected].
PMID: 25442320 DOI: 10.1016/j.bmcl.2014.09.055
Abstract

A phytochemical investigation on crude extract of Gentianella azurea led to the isolation of ten new (1-10) and one known (11) secoiridoid glycosides. Their structures were unambiguously elucidated by analysis of 1D and 2D NMR. Compounds 2, 5 and 11 were found to inhibit nitric oxide (NO) production in RAW 264.7 macrophages with IC50 values of 52.78 ± 8.61, 0.69 ± 0.23 and 5.18 ± 1.33, respectively, while indomethacin, the positive control, showed an IC50 value of 1.25 ± 0.52 μM.

Keywords
Anti-inflammatory; Gentianella azurea (Gentianaceae); Nitric oxide; Secoiridoid glucosides.