Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

  • Bioorg Med Chem Lett. 2015 Feb 1;25(3):621-5. doi: 10.1016/j.bmcl.2014.12.007.
Nahyun Kim  1 ,  Kyu-Won Cho  1 ,  Seong Su Hong  2 ,  Bang Yeon Hwang  3 ,  Taehoon Chun  4 ,  Dongho Lee  5
Affiliations
  • 1. College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea.
  • 2. College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea; Natural Products Research Institute, Gyeonggi Institute of Science and Technology Promotion, Suwon 443-270, Republic of Korea.
  • 3. College of Pharmacy, Chungbuk National University, Cheongju 362-763, Republic of Korea.
  • 4. College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea. Electronic address: [email protected].
  • 5. College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea. Electronic address: [email protected].
PMID: 25537268 DOI: 10.1016/j.bmcl.2014.12.007
Abstract

Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5μM.

Keywords
Antiproliferative effect; Dictamnus dasycarpus; Glabretal-type triterpenoid; Rutaceae.